APPLICATION NOTE

Drug metabolism in a gut-liver microphysiological system

Studying organ-organ interaction and crosstalk

Application note overview:

Studies investigating the efficacy and safety of candidate drugs use a variety of animal models to translate research from the bench to clinical trials and then to the clinic. These models remain an important part of preclinical research, but have limitations and concerns that include high cost, ethical use and their weakness as predictors of human biology.

Microphysiological systems (MPS) enable the generation of in vitro 3D organ models whose purpose is to accurately represent their human body counterparts.

To date, these systems mainly use single-organ models in isolation, however, more complex MPS models that incorporate multiple tissues related to ADME are required to further improve the prediction of in vivo PK/PD.

Using a multi-organ gut and liver microphysiological system (MPS), this study investigates the permeability of an orally administered drug through an intestinal barrier and its subsequent hepatic metabolism to establish if more accurate predictions of in vivo hepatic clearance rates are achieved using interconnected organs that operate in synergy, versus organs studied in isolation.

Authors:

Yassen Abbas, Tomasz Kostrzewski and David Hughes


Related webinar:

Towards a Body-on-a-Chip: The Value of Multi-Organ MPS for Human-Relevant Drug Assessment on 24 Mar at 15:00 (GMT). Watch here