Pharmacokinetic profiles revisited in 3D microfluidic tumour models

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Poster overview:

The efficacy or toxicity of a drug is dependent on the concentration at the target. This concentration varies with time owing to absorption, distribution, metabolism and excretion, resulting in a pharmacokinetic (PK) profile. Understanding the relationship between PK, pharmacodynamics (PD) and efficacy is critical to the successful development of new medicines. At present this relationship is primarily investigated using animals, this is time-consuming, ethically undesirable and prone to a lack of translation, particularly if animal and human PK differ significantly. This contributes to the low success rate of oncology medicines in the clinic.

At present there are a lack of in vitro alternatives to explore this relationship. In animals and humans drug concentration varies with time, whereas in vitro experiments are performed at fixed concentrations. This limits the translational relevance of the in vitro experiments.

Oncology Service

Our unique Oncology Service combines innovative technology with deep cell culture expertise to enable a first – the in vitro exploration of the relationship between PK/PD and efficacy.

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Tudor Petreus, Dharaminder Singh, David Hughes and Tomasz Kostrzewski

CN Bio, Cambridge, UK